This course will explore the versatility of non-coding RNAs, a diverse and prevailing class of transcripts that engage in numerous biological processes across every branch of life in all living organisms from bacteria to humans. Word-famous researches will expose their very last discoveries in identification and biogenesis to functional roles of non-coding RNAs in physiology and human disease. It will provide an opportunity to young students and research fellows to discuss their work with an international scientific community in a warm and stimulating environment of Institut Curie.
The aim of this course is to provide an overview of epigenetic mechanisms and their link to chromatin dynamics. The different functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear functions and the development of human pathologies will be discussed.
The success of the course relies on the active contribution of participants who are expected to be proactive and to participate in all of the events organized including:
i) presentation of their own scientific project with a poster
ii) participation in the Journal Club to both present and review key articles proposed by the speakers,
iii) participation to the “career development” workshop during the Saturday morning and the “epi-Courses” such as the “Art & Science” workshop.
A special session will be devoted to 2 or 3 alumni who have gone on to successful careers in the field of Epigenetics. Everything is in English.
The aim of this course is to better understand the nature of scientific knowledge, appreciate its role in our society and face the ethical issues raised by its development.