September 16th-20th 2019, Roscoff, FR – Genome instability: when RNA meets chromatin
Research in the last two decades has revealed a surprising interplay between the DNA Damage Response (DDR) and RNA biology. It has been shown that transcription and RNA processing can interfere with DNA replication, thus becoming a serious potential threat to genome stability. Reciprocally, DNA lesions able to interfere with replication and transcription globally impact on different steps of RNA metabolism including RNA splicing and stability. In addition, recent observations suggest a potential important role of non-coding RNAs in the DDR. Finally, RNAs also act as key players regulating histones modifications, chromatin and chromosome organization that further influence all DNA metabolic processes from replication to repair. Altogether this recent research puts RNA as a key molecule in the whole network of DDR with both a potential positive and negative role in genome integrity, and DDR has emerged at the center of this complex interplay between DNA synthesis, transcription, RNA processing and chromatin, with major consequences for genomic instability. The aim of this Jacques Monod conference is to bring together experts from these different rapidly-changing fields in order to discuss the most recent results on these novel and important issues. In particular, we expect to discuss the following topics: a) Transcription and RNA as threats; b) Replication conflicts; c) Nuclear compartments and the DDR; d) DSB repair; e) The RNA in the DDR; e) Chromatin modifications in genome integrity, and f) Mechanisms of telomere integrity.
For more information visit this LINK
April 1st-3rd 2019, Munich, DE – Chromatin and Epigenetics: Inheritance and Design
This exciting three day conference bridges chromatin mechanisms and epigenetic phenomena – two key pillars of modern biology. The conference will cover the latest advances in the chromatin field, ranging from basic molecular mechanisms of transcriptional regulation to designing and manipulating epigenomes and epigenetic pathways in development, disease and reprogramming across model systems.
For more information visit this LINK
Mai 1st-4th 2019, Heidelberg, EMBL – Chromatin and Epigenetics
EMBO Workshop. Asifa Akhtar, Geneviève Almouzni, L. Stirling Churchman, Ana Pombo, Chris Pointing
Epigenetics refers to heritable change in gene expression that does not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation. Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases. Moreover influence of age, environment, lifestyle, and disease state on epigenetic states is being increasingly appreciated and actively studied.
This conference provides an international forum for cutting edge research in chromatin and epigenetics. It provides the « focal hub” for people to present their research and exchange ideas in a European venue. Renowned speakers will cover the latest advances in the field, including chromatin regulation, chromatin dynamics, signalling to chromatin, nuclear architecture and dynamics, developmental epigenetics, epigenomics, epigenetics and human diseases, genome stability, environmental epigenetics, and transgenerational inheritance.
- Epigenetic reprogramming
- Developmental epigenetics
- Different states of chromatin
- Histone modifications, RNA and metabolism
- Transcriptional and posttranscriptional regulation
- Nuclear architecture
- Chromatin and its variants in disease
Oct 6th-10th 2019, GR-Crete – Histone chaperones: Structure, function and role in development and disease
EMBO Workshop. Contact: Jessica Tyler