Conférences externes

Conferences on gene regulation

Conferences & Schools – 2019

Genome Architecture in Cell Fate and Disease
August 4 – 9, 2019 | Hong Kong, CN

The rules that dictate spatial and temporal organization of genomes are rapidly being elucidated through advances in the molecular manipulation of genomes, methods to measure proximity and dynamics in the cell nucleus, single cell measurements, microscopic imaging, biophysical principles and computational modeling. This hierarchical organization can be viewed at many scales, all of which are dynamically altered to regulate transcription, replication, genome integrity and the changes in epigenetic states that define different cell types. Increasingly, we find evidence for causal linkages between alterations in 3D genome organization and disease. The 2019 conference on Genome Architecture in Cell Fate and Disease “The Eukaryotic Genome in 4 Dimensions: Integrative Approaches to Bridging Genotype and Phenotype” is the third meeting of its kind and will seek to promote interdisciplinary discussion of the most cutting edge principles in this field, including the latest technologies and concepts, relationships to chromosome function including development, disease, genome integrity and epigenetic inheritance.

For more information visit this LINK

Cell Cycle Meeting
June 3-6, 2019 | Trieste, Italy

The 2019 Cell Cycle Meeting in Trieste, Italy, will highlight the ‘diversity in cell cycle control mechanisms’, exploring cell cycle control in different organisms, focusing on the similarities and differences in fundamental properties, to elucidate the wiring of cell cycle control networks in health and disease. This meeting will be the first of a biannual European meeting to alternate with the well-established Salk Cell Cycle meetings in California, USA. By coordinating with the Salk Cell Cycle meetings and inviting a large number of speakers from outside Europe the Cell Cycle Meeting in Trieste will draw a truly global attendance from the international cell cycle community (see our program). This will provide a larger international community with an opportunity to merge and share ideas.

For more information visit this LINK

Epigenetic Mechanisms Across Scales: From Molecules to Environment and Evolution
July 21 – 26, 2019 | Holderness, NH, USA

The epigenetics field stands on a strong foundation based on analysis of deviations from genetic rules. In recent years, we have witnessed an ever-growing interest in the mechanisms underlying epigenetic phenomena, along with novel approaches to study them. At our 2019 GRC on Epigenetics, we will cover fundamental aspects of epigenetic memory and inheritance, genome evolution, and the regulatory impact of repetitive elements, as well as our current understanding of the principles of nuclear organization and gene regulation. These topics will include environmental influences and novel biophysical and quantitative approaches, and will feature different model systems and experimental strategies.

For more information visit this LINK

Biology at different scales
May 27 – June 7, 2019 | Les Houches, France

This school focuses on the interplay between physics and biology to understand biological processes at different scales, from the molecular level to living organisms. The school is aimed at PhD students and early-stage researchers trained in various fields and with an interest in biology. Participants are shown how a biological problem can be tackled using an integrated approach. The school also aims at showing how physics and mathematics can contribute to model biological processes.

For more information visit this LINK

Chromosome segregation and aneuploidy
11 – 15 May 2019 | Cascais, Portugal

This EMBO Workshop is the premier venue to bring together the fields converging on aneuploidy, including chromosome copy number variation, chromosomal abnormalities, chromosome missegregation, and mitotic failure. Aneuploidy is one of the most prominent hallmarks of cancers, yet a causative role is still a matter of active research. Further, inborn chromosome number imbalance such as in trisomy 21 (Down syndrome) or XYY syndrome are a direct consequence of germ-line derived chromosome segregation defects. Mechanisms of chromosome segregation and failure thereof has its origins in many aspects of the cell division cycle that include chromosome architecture, chromosome conhesion and condensation, centromere and kinetochore assembly, spindle function, and centriole and centrosome function. This workshop aims to interface between these fields. We mix basic, fundamentals with applied and preclinical work in an open friendly environment, bringing together scientists from all career levels, from anywhere in the world in an intimate venue mixing short talks and posters with main presentations by world experts.

For more information visit this LINK

Genetic, Molecular and Physical Views of Genomes and Their Organizational Principles
June 23 – 28, 2019 | Newry, ME, USA

The information in chromosomes – nucleic acid sequences of long chromosomal DNAs – controls the lives of all organisms. Far from being inert genetic data storage elements, chromosomes are increasingly being seen as highly dynamic organelles involved in a wide range of cellular functions. Chromosome biology is an interdisciplinary field studied by a large and diverse set of scientists using a broad set of experimental methods, with just the past few years having seen remarkable steps forward in our molecular understanding of how chromosomes are organized by the cell. This GRC aims to bring together the leaders of this field to share their cutting-edge results and to work together to further develop interdisciplinary approaches that and seed further advances in the understanding of chromosome structure and dynamics.

For more information visit this LINK

The genome in three dimensions
20 – 24 May 2019 | Kyllini, Greece

It is now well accepted that our genome is much more than a passive, one-dimensional, storage unit of genetic information. Advances over the last decade alone have paved new and exciting ways for studying genomes as three-dimensional entities with distinct temporal dynamics. Such studies are helping us explain the overarching architecture of chromosomes and their regulatory plasticity. Nonetheless, this field of study is rapidly evolving and new technologies, new challenges, and new insights into the structure-to-function relationship of genomes emerge every day. As a result, this EMBO Workshop will bring together established and younger experts for four days of focused discussions on (i) the contribution of chromatin topology in homeostasis and disease, (ii) the mechanistic basis of chromatin looping and spatial communication between regulatory elements and genes, as well as on (iii) recent experimental and computational modeling advances for dissecting genomic architecture and its dynamics. Ultimately, we will be seeking to unify and integrate views and data to obtain an updated and coherent appreciation of how chromosomes are folded in order to execute their functions.

For more information visit this LINK

Mitotic and Meiotic Cell Cycle control and execution
April 8-12, 2019 | Roscoff, France

The accurate, appropriate and timely control and execution of cell division regulates virtually every aspect of biology from proliferation through development to disease. Universal as cell division is, there is great variation in the contexts, rates and topology within which the cell cycle is triggered and executed. Each distinct circumstance, be it an isolated cell in a unique nutrient environment or, a particular cell in a particular tissue, imposes distinct demands upon the core cell cycle control and genome segregation machinery. Cell division control and execution must therefore be remodelled to suit a spectrum of contexts, niches, or the more radical demands to reduce, or eliminate, the genome compliment. While repeated rounds of symmetrical division maybe favoured by some cell types, many stem cells maintain stemness through asymmetrical division, germ cells pursue reductional divisions and cancer cells often appear to ignore the rule book and divide however they possibly can. Insight into such diversity and control continues to reveal how much more there is to learn about cell and nuclear division. The Conferences Jacques Monod meetings on the Cell Cycle provide a unique forum for discussing and debating these principles and the latest revelations in the field. The next meeting in this series will be no exception. A stellar line up of international speakers will be describe their research at the cutting edge of the cell cycle and division fields to set the scene for engaging debates in the beautiful setting of the CNRS Roscoff Marine Research Station. The intimate scale of these meetings (115 attendees in total), means that, in the likely scenario of over-subscription, the organisers may approach the heads of labs from whom multiple applications have been received to select one candidate for attendance.

For more information visit this LINK

September 16th-20th 2019, Roscoff, FR – Instabilité du génome : lorsque l’ARN rencontre la chromatine

La recherche des deux dernières décennies a révélé une interaction surprenante entre la réponse aux dommages à l’ADN (DDR) et la biologie des ARN. La transcription et la maturation des ARN peuvent interférer avec le processus de réplication, menaçant ainsi la stabilité du génome. Réciproquement, les lésions à l’ADN qui interfèrent avec la transcription et la réplication, ont également des conséquences sur le métabolisme des ARN, tels que l’épissage, ou encore la stabilité des ARN. De plus des observations récentes suggèrent un rôle potentiel des ARN non codant dans la DDR. Enfin, les ARN jouent un rôle essentiel dans la régulation des modifications d’histone, de la structure de la chromatine et dans l’organisation des chromosomes, eux même au cœur de la régulation du métabolisme de l’ADN tels que la réplication et réparation. L’ensemble de ces études placent ainsi les ARN au cœur des processus impactant la stabilité du génome, à la fois comme menace et comme mécanismes de réparation, et la DDR a émergé au centre de ces interactions complexes entre synthèse d’ADN, production et métabolisme des ARN et chromatine. Le but de cette conférence Jacques Monod est de rassembler des scientifiques experts dans ces différents champs d’investigation, afin de discuter et d’échanger les résultats les plus récents Plus particulièrement la conférence couvrira 1) les ARN en tant que menace pour la stabilité du génome, 2) les conflits entre transcription et réplication, 3) la réponse aux dommage en lien avec l’organisation nucléaire, 4) les mécanismes de réparation des cassures double brins de l’ADN, 5) le rôle des ARN dans la DDR, 6) le rôle des modifications de la chromatine dans la stabilité des génomes et enfin 7) les mécanismes assurant l’intégrité des télomères.

For more information visit this LINK

April 1st-3rd 2019, Munich, DE – Chromatin and Epigenetics: Inheritance and Design

This exciting three day conference  bridges  chromatin mechanisms and epigenetic phenomena – two key pillars of modern biology. The conference will cover the latest advances in the chromatin field, ranging from basic molecular mechanisms of transcriptional regulation to designing and manipulating epigenomes and epigenetic pathways in development, disease and reprogramming across model systems.

For more information visit this LINK

May 1st-4th 2019, Heidelberg, EMBL – Chromatin and Epigenetics

EMBO Workshop. Asifa Akhtar, Geneviève Almouzni, L. Stirling Churchman, Ana Pombo, Chris Pointing

Epigenetics refers to heritable change in gene expression that does not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation. Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases. Moreover influence of age, environment, lifestyle, and disease state on epigenetic states is being increasingly appreciated and actively studied.

This conference provides an international forum for cutting edge research in chromatin and epigenetics. It provides the « focal hub” for people to present their research and exchange ideas in a European venue. Renowned speakers will cover the latest advances in the field, including chromatin regulation, chromatin dynamics, signalling to chromatin, nuclear architecture and dynamics, developmental epigenetics, epigenomics, epigenetics and human diseases, genome stability, environmental epigenetics, and transgenerational inheritance.

Session Topics

  • Epigenetic reprogramming
  • Developmental epigenetics
  • Different states of chromatin
  • Histone modifications, RNA and metabolism
  • Transcriptional and posttranscriptional regulation
  • Nuclear architecture
  • Chromatin and its variants in disease

Oct 6th-10th 2019, GR-Crete – Histone chaperones: Structure, function and role in development and disease

EMBO Workshop. Contact: Jessica Tyler